2026 is 30 Year Anniversary!
jClamp for Windows (v. 42.4.0) is a
user-friendly whole-cell voltage clamp data acquisition program which features
real time monitoring of cell and voltage clamp characteristics. At all times
the patch clamper can determine cell status. Data collection is initiated
through a rapid parameter directory (RPD) which maintains a list of 18
parameter filenames or script filenames. Either a key press or mouse click
begins the predefined voltage or current delivery protocols. Scripts are text
files which allow groups of parameter files to be called and run. Most tasks
are automated. Some data analysis is available. In addition, automation links
with MATLAB, Excel, SigmaPlot and Origin are
available.
- jClamp32
- $3,995 for educational institutions. Contact me for non-Ed costs. Download
Windows MSI installation file (jclamp32_v42.4.0.msi) at bottom of page. As
always, free updates. Please cite jClamp in your published manuscripts.
- jClamp
(v. 31.6.1 and above) is now FREE to use with the Axon Digidata
1320 series, Axon 1200A & 1200B and the old Labmaster
DMA!!! See supported hardware for more information Email
me so I can keep track of users. 
Access Web Help:
jClamp Help
Access PDF
Help: jClamp
PDF Help
Attention parents! Get Merlin
Programmer for Kids, an absolutely FREE fun program I wrote to help my kids
(now adults) and yours (ages 5-8) learn how to program within Windows and
hopefully (ultimately) help support their higher education, but more
importantly help them to think logically! Works with Win10 - use compatibility
with Win95.
Nanion Port-o-Patch support is here!
You
can see supported hardware info (here).
New Feature Update
> -3/10/26 Version 42.4.0
> Potential bug fixes and enhancements. Support for plotting Re, Im and Abs complex Cm for 2-sine data in Analysis Window. Fixed issues of plotting in IV and fits.
> -1/27/26 Version 42.3.0
> Potential bug fixes. Export data file fixes. Dynamic clamp update.
> -1/17/26 Version 42.2.0
> Fit form enhancements. IV plotting fixes.
jClamp instance usage updated. Now additional instances of jClamp cannot be run with the same Inifile, except for
math_model.ini or jclamp32.ini. If there is a conflict then math_model.ini will be used. Message box gives information
when several instances are used. Also, indications of jClamp start and graceful exit are written
in jClamp directory as text files without file extensions. They can be read with text editor.
> -1/11/26 Version 42.1.0
> Enhancements and
potential bug fixes. Dynamic Clamp in Windows with the NI PCIe-6374 board.
Timing is via QPC with pt by pt in/out. Jitter (clock +/- SD) is saved for
inspection. Usually, SD is about 10% for a 10us clock. Many other features.
Current clamp mode is dynamic, while voltage clamp is model evaluation only. A
few dynamic HH models are included. Above see Ik in CC window and in Analysis
mode a voltage-dependent capacitance inserted into a linear electrical model
using an Axon 200B amplifier. Contact me if you want more information.
> -9/24/25 Version 40.1.0
> Enhancements and
potential bug fixes. Print to PDF (Adobe and Microsoft) updated to not only
print all data plots in a directory, but to print all protocol forms to view
all your command protocols. Optimal printing of 8 data plots or protocols per
page. Fixed automatic fitting of traces during batch plotting from Data Load
window. Ability to save to text file
fit results during batch plotting.
> -9/7/25 Version 40.9.0
> Fixed timed evaluation
license issue. Math model enabled/disabled only in ini
file (not anymore in CC pop-up window), ensuring full ini
file implementation of model settings. Any hardware designed (e.g., NI usbx board) ini file can be used
to analyze collected data with/without hardware present if model is enabled in
in file. Load jClamp with model enabled ini can be
run as a new instance of jClamp even during a jClamp instance with enabled
hardware. Math model window is shown at startup if model is selected in ini file. Re-initialization issues fixed within jClamp.
Upon ini file load, if hardware is absent or cannot
be initialized, then the math model jClamp32.ini file is loaded. To use
hardware, make sure that manufacturer designed software associated with the
hardware works, e.g., that Axoscope works with the
Axon 1550B digitizer. Then retry the hardware enabled ini
file.
> -9/3/25 Version 40.8.0
> Fixed bug in abf file export..
> -9/1/25 Version 40.7.0
> Touch ups. Bug fixes.
Adobe PDF printing enahancement. Auto directory and
filename or user choice. Use Adobe Printer. MS Print to PDF is bad and no options. Result Window remains user chosen size
before/after switch to Analysis mode. Clipboard copy
for all plots. Enhanced Matlab data export. Fixed occasional crash when
repeatedly switching between time and frequency domain in CC.
> -8/12/25 Version 40.6.0
> Touch ups. Bug fixes.
> -8/1/25 Version 40.5.0
> Touch ups. Bug fixes.
Axon fix for DigiData 1550B FPGA file now. No more
spurious voltage pulses that could have injured recorded cells. Axon 1550 and
1550A may still have bug. Episode averaging fix.
> -6/14/25 Version 40.4.0
> Cumulative changes
since version 39.0.0. Ability to additionally save a polynominal
fitted calibration file whose use could reduce effects of noise in calibration.
Touch ups.
> jClamp will now notify
you if the disk space on the data drive is less than 1 GB at startup or after a
data collection is made. To change the default size, edit in inifile under Script tab. IniEditor
and JcLog forms can be set to modal/topmost with
push-pin button. Touch ups.
> Fixed bug to allow
current monitoring in CC when CC is off and telegraphs are not enabled. Do a
new system calibration. Touch ups.
> Fixed minimize/maximize
jClamp window, calibration display. Touch ups.
> Fixed plot comparison
in Result window. Fixed pauses during averaging of large number of collections.
Touch ups.
> Plotting bug fixs. New command protocol to increment resolution of 2 sine cm protocol across 5 episodes; epFinc
select in command window.
> Re-initialization bug
fix. Audio Clip monitor fix.
> Audio Clip enhancement.
Look32x! fixes. Axon 1550B jClamp CC modification to minimize driver problems.
The board still produces spurious voltage pulses, however. Molecular Devices is finally investigating.
> Touch ups. Bug fixes.
Fixed sometimes stalled Look32x video collection from parameter files. More PSD
enhancements.
> Touch ups. Bug fixes.
Single sine PSD Cm measure window and export enhancements. Data directory
opened on right click free space info panel.
jClamp Features and Previous updates
Files
may be downloaded for a trial examination.
email me for a 30 day
hardware license; please include your affiliation, operating system and
hardware.
I suggest a fast
computer (>1GHz), at least 512 Meg memory, and fast video! jClamp is a large
program. It works best in Win NT, 2000, XP, Vista or Win7/8 - for those boards
which can work in these environments. Cm tracking with the Axon 1200 board has
problems in Win NT if run from Cell Censor but not within command protocols.
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jClamp Help file (jclamp32.chm); to view you may need to unblock in the security tab of the file properties (alternatively, see Web Help above) |
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10-Mar-2026 |
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New 32 bit (v 42.4.0) version setup files [there may be a quickie update jc_exe*.exe that could be available during update check]. The new jClamp version will work in Windows Win11/Win10/Win7/Vista/XP/NT/2000/Me and /98. See above for features. Per-machine license required. Software demo license included. Time-limited hardware license see below. Read getting started.
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installed Axon driver files |
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Email me. 30 day hardware license for evaluation of jClamp or FastLook. Rename to jclamp32.lic and replace the software-only license file in the jclamp32 directory, or rename to fastlook.lic and replace the software-only license file in the fastlook directory. |
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Connect to Axon Instruments to
download Axoscope and the Digidata
drivers for Win95/98 and WinNT
Copyright
1996-2026 J. Santos-Sacchi [SciSoft]
Last modified: Mar 10, 2026 (hg)
